Natural Satiety Mechanism | Systemic Delivery | Topical Lingual Delivery
Natural Satiety Mechanism
1. Satiety normally results from the release of many hormones triggered by a meal.
2. These hormones circulate throughout body stimulating brain centers responsible for controlling hunger. The hormones also promote beneficial effects in the periphery, such as slowed gastric emptying, increased insulin sensitivity, etc.
Systemic Delivery
3,4. Therapeutically raising the systemic levels of any one of these hormones provides many of the benefits of the natural hormone response but also simultaneously activates the brain’s satiety and nausea centers.
Topical Lingual Delivery
Via Glossopharyngeal Nerve
1. Hormones in saliva bind to receptors in the mouth.
2. The glossopharyngeal nerve carries the signals directly to the satiety centers in the brainstem and hypothalamus without activating nausea centers.
Bypassing Nausea
The core of Gila’s approach is based on signaling via oral receptors to activate specific target areas of the brain responsible for metabolic regulation while avoiding areas responsible for side effects such as nausea.
Provides better weight loss than other GLP-1RAs, possibly because of its greater hydrophobicity, giving it better access to key satiety centers in the CNS. Yet its market penetration is still limited because of side effects (nausea), inconvenience (injections) and cost.
No systemic exposure, zero nausea. We directly access the satiety centers, activating them more strongly than any systemic treatment, because dosing is not limited by nausea. Our robust animal data, as well as our Phase I human data, indicate that there are ample receptors in the mouth and the neural connections have sufficient bandwidth to fully activate the satiety
| Affected |
GLP-1RA Systemic Delivery |
PYY Targeted Delivery |
|---|---|---|
|
Blood |
⬤ |
|
|
Saliva |
⬤ |
⬤ |
|
Hypothalamus |
⬤ |
⬤ |
|
NTS |
⬤ |
⬤ |
|
Area Postrema |
⬤ |
|