Natural Satiety Mechanism | Systemic Delivery | Topical Lingual Delivery
Natural Satiety Mechanism
1. Satiety normally results from the release of many hormones triggered by a meal.
2. These hormones circulate throughout body stimulating brain centers responsible for controlling hunger. The hormones also promote beneficial effects in the periphery, such as slowed gastric emptying, increased insulin sensitivity, etc.
Systemic Delivery
3,4. Therapeutically raising the systemic levels of any one of these hormones provides many of the benefits of the natural hormone response but also simultaneously activates the brain’s satiety and nausea centers.
Topical Lingual Delivery
Via Glossopharyngeal Nerve
1. Hormones in saliva bind to receptors in the mouth.
2. The glossopharyngeal nerve carries the signals directly to the satiety centers in the brainstem and hypothalamus without activating nausea centers.
Bypassing Nausea
Systemically delivered GLP-1RAs effectively activate satiety centers. However, circulating these hormones at levels sufficient to produce satiety also activates the neurological area responsible for nausea: the Area Postrema.
By delivering PYY hormones to the tongue, Gila activates the same satiety centers by a more direct route, without increasing hormone blood levels. Bypassing nausea, Gila’s tongue-to-brain signaling allows full dosing & activation without ill side-effects.
| Affected Y/N? |
GLP-1RA Systemic Delivery |
PYY Targeted Delivery |
|---|---|---|
|
Blood |
⬤ |
|
|
Saliva |
⬤ |
⬤ |
|
Hypothalamus |
⬤ |
⬤ |
|
NTS |
⬤ |
⬤ |
|
Area Postrema |
⬤ |
|